XL765(SAR245409)


Catalog No:LP000274
Product Name:MP470
CAS No:1349796-36-6
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
Phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (Item No. 13346) (mTOR) constitutively signal and drive cell survival and proliferation in many forms of cancer.1,2 XL765 is a dual inhibitor of both PI3K and mTOR, completely blocking phosphorylation of substrates at 8-16 µM.3,4 Similarly, XL765 is cytotoxic to glioblastoma multiforme (GBM) xenografts in vitro, with half maximal inhibition occurring at 3.7-7.7 µM.4 XL765 is orally bioavailable and passes the blood-brain barrier, reducing the growth of intracranial GBM xenografts in mice.4 This inhibitor is effective alone or in combination therapy with other compounds in various types of cancer.

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