Cat No:LP000275
Product Name:XL019
CAS No:945755-56-6
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F).1 Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma.2 XL019 is a potent, bioavailable JAK inhibitor with preference for JAK2 (IC50 = 2 nM) over JAK1 and JAK3 (IC50s = 130 and 250 nM, respectively).3,4 It is effective against JAK2V617F as well as JAK2 and inhibits phosphorylation of STAT5 in vivo.
