CAS No. 508233-74-7 Cat. No. BCP05996
Related Products 960203-27-4(Vortioxetine hydrobromide)
Name Vortioxetine
Synonyms Lu AA 21004;LuAA21004; Lu-AA21004; Lu AA21004; AA21004; AA-21004; AA 21004;
Chemical Name
Formula C18H22N2S M. Wt 298.45
Purity 98% Storage Store at 4-8°C
Description Vortioxetine, also known as Lu AA21004, is an atypical antidepressant, and was approved in 2013 by the U.S. FDA for the treatment of major depressive disorder (MDD) in adults. Vortioxetine is a so-called “serotonin modulator and stimulator.” It has been shown to possess the following pharmacological actions: Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) — Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM; Norepinephrine transporter (NET) blocker — Ki = 113 nM; 5-HT1A receptor high-efficacy partial agonist/near-full agonist — Ki = 15 nM, IA = 80%; 5-HT1B receptor partial agonist — Ki = 33 nM; 5-HT1D receptor antagonist — Ki = 54 nM; 5-HT3A receptor antagonist — Ki = 3.7 nM; 5-HT7 receptor antagonist — Ki = 19 nM.

Leave a comment

Your email address will not be published. Required fields are marked *