Name: JZL184 CAS#: 1101854-58-3 Chemical Formula: C27H24N2O9 Exact Mass: 520.1482 Molecular Weight: 520.49 Elemental Analysis: C, 62.30; H, 4.65; N, 5.38; O, 27.67Description: JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively. IC50 value: 8…
Author: admin
SGX-523
Name: SGX-523 CAS#: 1022150-57-7 Chemical Formula: C18H13N7S Exact Mass: 359.09531 Molecular Weight: 359.41 Elemental Analysis: C, 60.15; H, 3.65; N, 27.28; S, 8.92 Description: SGX523 is a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L and is >1,000-fold selective versus the >200-fold…
JNJ38877605
Name: JNJ-38877605 CAS#: 943540-75-8 Chemical Formula: C19H13F2N7 Exact Mass: 377.12005 Molecular Weight: 377.35023 Description: JNJ-38877605 is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. c-Met inhibitor JNJ-38877605 selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis. c-Met is also known…
IC-87114
Name: IC-87114 CAS#: 371242-69-2 Chemical Formula: C22H19N7O Exact Mass: 397.16511 Molecular Weight: 397.43 Elemental Analysis: C, 66.49; H, 4.82; N, 24.67; O, 4.03 Description: IC-87114 is a potent and ATP-competitive PI3K p110δ isoform-selective inhibitor (IC50 = 60 nM). It Inhibits p110α, p110β and p110γ only at much higher concentrations. It does not inhibit other PIK-related…