Products – Page 717

VS-5584

Oct 13, 2017adminActive small molecule, Products1246560-33-7, SB2343, VS-5584

Cat No:LP000035 CAS NO: 1246560-33-7 Molecular Formula:C17H22N8O Molecular Weight: 354.41 Purity: ≥98% Solubility:In DMSO Storage:-10°C VS-5584 is an ATP-competitive inhibitor which selectively inhibits PI3K/mTOR signaling with equivalent low nanomolar potency against all human Class I PI3K isoforms and mTOR kinase. VS-5584 (0.001, 0.01, 0.1,1,10 and 100 μM) preferentially inhibits cancer stem cells in HMLE breast […]

Alpelisib

Cat No:LP000034 CAS NO: 1217486-61-7 Molecular Formula: C19H22F3N5O2S Molecular Weight: 441.47 Purity: 98% min Solubility: In DMSO Storage: -20°C BYL-719 (NVP-BYL719) potently inhibits the 2 most common PIK3CA somatic mutations (H1047R, E545K; IC50~4 nM). BYL-719 potently inhibits Akt phosphorylation in cells transformed with PI3Kα (IC50=74±15 nM) and shows significant reduced inhibitory activity in PI3Kβ or […]