Products – Page 684

AT-101;(R)-(-)-Gossypol; R-(-)-gossypol acetic acid

Feb 23, 2018adminActive small molecule, Products(R)-(-)-Gossypol; R-(-)-gossypol acetic acid, 90141-22-3, AT101

Cat No:LP000114 Product Name:AT-101 CAS NO:90141-22-3 Purity: ≥99% Solubility: In DMSO Storage: -10°C The natural racemic Gossypol has two enantiomers, namely the AT-101 ((-)-Gossypol) and (+)-Gossypol enantiomers. AT-101 and (+)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities, AT-101 is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis, possibly […]

Ponatinib

Cat No:LP000113 Product Name:AP24534,Ponatinib CAS NO:943319-70-8 Purity: ≥99% Solubility: In DMSO Storage: -10°C Ponatinib (AP24534) potently inhibits native ABL (IC50: 0.37 nM), ABLT315I (IC50: 2.0 nM), and other clinically important ABL kinase domain mutants (IC50: 0.30-0.44 nM). Ponatinib also inhibits SRC (IC50: 5.4 nM) and members of the VEGFR, FGFR, and PDGFR families of receptor […]