Active small molecule – Page 242

JNJ38877605

Sep 5, 2018adminActive small molecule943540-75-8, JNJ38877605

Name: JNJ-38877605 CAS#: 943540-75-8 Chemical Formula: C19H13F2N7 Exact Mass: 377.12005 Molecular Weight: 377.35023 Description: JNJ-38877605 is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. c-Met inhibitor JNJ-38877605 selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis. c-Met is also known […]

IC-87114

Name: IC-87114 CAS#: 371242-69-2 Chemical Formula: C22H19N7O Exact Mass: 397.16511 Molecular Weight: 397.43 Elemental Analysis: C, 66.49; H, 4.82; N, 24.67; O, 4.03 Description: IC-87114 is a potent and ATP-competitive PI3K p110δ isoform-selective inhibitor (IC50 = 60 nM). It Inhibits p110α, p110β and p110γ only at much higher concentrations. It does not inhibit other PIK-related […]