Name: SB-271046 HCl
CAS#: 209481-24-3 (HCl)
Chemical Formula: C20H23Cl2N3O3S2
Molecular Weight: 488.442
Elemental Analysis: C, 49.18; H, 4.75; Cl, 14.52; N, 8.60; O, 9.83; S, 13.13
Description: SB-271046 is one of the first selective 5-HT6 receptor antagonists to be discovered. SB-271046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood–brain barrier. SB-271046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5-HT6 antagonists have been shown to produce nootropic effects in a variety of animal studies. Suggested applications of these drugs include treatment of schizophrenia and other psychiatric disorders.