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Name: Vicriviroc maleate
CAS#: 599179-03-0 (maleate)
Chemical Formula: C32H42F3N5O6
Exact Mass:
Molecular Weight: 649.7122
Elemental Analysis: C, 59.16; H, 6.52; F, 8.77; N, 10.78; O, 14.77
Description: Vicriviroc, also known as SCH 417690 and SCH-D, is a potent, orally active and selective CCR5 entry inhibitor of HIV-1. Vicriviroc is effective at nanomolar concentrations, it can be administered once daily. Vicriviroc binds to a small hydrophobic pocket between the transmembrane helices near the extracellular surface of the CCR5 receptor. Binding to this pocket induces a conformational change of the extracellular segment of CCR5 and prevents binding of gp120 to the target cell, consequently preventing the virus from entering the target cell at all.

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