LookPharma – Page 607 – Look Pharma Limited

AZD1080

Feb 25, 2018adminActive small molecule, Products612487-72-6, AZD1080

Cat No:LP000268 Product Name:AZD1080 CAS No:612487-72-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C AZD1080 shows selectivity against cdk2 (pKi=5.9; 1150 nM; 37-fold), cdk5 (pKi=6.4; 429 nM; 14-fold), cdk1 (pKi=5.7; 1980 nM; 64-fold) and Erk2 (pKi< 5; >10 μM; >323-fold). AZD1080 (at 10 μM) is also evaluated for pan-kinase selectivity and showed good overall selectivity versus […]

RGFP966

Feb 25, 2018adminActive small molecule, Products1357389-11-7, RGFP966

Cat No:LP000267 Product Name:RGFP966 CAS No:1357389-11-7 Purity: ≥99% Solubility: In DMSO Storage: -10°C RGFP966 potently and selectively inhibits HDAC 3 with IC50 of 0.21 μM in RAW 264.7 macrophages, while HDACs 1 (IC50=5.6 μM), 2 (9.7 μM) and 8 (>100 μM), indicating a good level of selectivity for HDAC 3. The mRNA levels of HDACs […]