Cat No:LP000276 Product Name:RKI-1447 CAS No:1342278-01-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C RKI-1447 is an inhibitor of the Rho-associated kinases ROCK-I and II (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase.1 In cancer cells, RKI-1447 at a concentration of 100 nM has been […]
Cat No:LP000275 Product Name:XL019 CAS No:945755-56-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the […]