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PF-06447475

Jun 20, 2018adminActive small molecule, Products1527473-33-1, PF-06447475

Cat No:LP000318 Product Name:PF-06447475 CAS#1527473-33-1 Molecular Formula:C17H15N5O Molecular Weight:305.33 PF-06447475 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 3 nM), an enzyme genetically linked to Parkinson’s disease that interacts with parkin, a ligase whose loss of function leads to dopaminergic cell death.1 PF-06447475 has been shown to attenuate α-synuclein-induced dopaminergic neurodegeneration and […]

XY1

Cat No:LP000317 Product Name:XY1 CAS#1624117-53-8 Molecular Formula:C17H19N3O2 Molecular Weight:297.35 Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.1,2 SGC707 (Item No. 17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below […]