Cat No:LP000318
Product Name:PF-06447475
CAS#1527473-33-1
Molecular Formula:C17H15N5O
Molecular Weight:305.33
PF-06447475 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 3 nM), an enzyme genetically linked to Parkinson’s disease that interacts with parkin, a ligase whose loss of function leads to dopaminergic cell death.1 PF-06447475 has been shown to attenuate α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2-expressing rats.
