Cat No:LP000024 Product Name:GDC-0084;RG7666 CAS:1382979-44-3 Purity:99%+ In Stock GDC-0084 (Compound 16) maintains inhibition of each of the Class I PI3K isoforms but with more potent inhibition of mTOR. GDC-0084 is also tested in five different GBM cell lines and is found to have antiproliferative EC50s ranging from 0.3 to 1.1 μM[1]. After a 25 mg/kg […]
Cat No:LP000023 Product Name:JNJ-31020028 CAS:1094873-14-9 Purity:99%+ In Stock JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. IC50 value: 8.07/8.22(human/rat pIC50) [1] Target: Y2 receptor antagonist in vitro: JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04 +/- 0.13) in […]