Products – Page 687

Neratinib

Feb 23, 2018adminActive small molecule, Products698387-09-6, HKI-272, Neratinib

Cat No:LP000108 Product Name:Neratinib,HKI-272 CAS NO:698387-09-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer.1,2 Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 […]

Pelitinib

Feb 23, 2018adminActive small molecule, Products257933-82-7, EKB-569, Pelitinib

Catalog No:LP000107 Product Name:Pelitinib,EKB-569 CAS NO:257933-82-7 Purity: ≥99% Solubility: In DMSO Storage: -10°C Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).1 It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).1 By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth […]