Cat No:LP000122 Product Name:Linagliptin;BI 1356 CAS No:668270-12-0 Purity: ≥99% Solubility: In DMSO Storage: -10°C Linagliptin inhibits DPP-4 activity in vitro in several independent experiments with IC50 values of 0.4, 0.5, 0.9, and 1.1 nM (mean IC50, approximately 1 nM). Linagliptin inhibits FAP with an IC50 of 89 nM (approximately 90-fold selectivity versus DPP-4)[2]. In male […]
Cat No:LP000121 Product Name:Cabozantinib;XL184;BMS-907351 CAS No:849217-68-1 Purity: ≥99% Solubility: In DMSO Storage: -10°C Cabozantinib is a potent inhibitor of MET and VEGFR2 with IC50 values of 1.3 and 0.035 nM, respectively. MET-activating kinase domain mutations Y1248H, D1246N, or K1262R are also inhibited by Cabozantinib (IC50=3.8, 11.8, and 14.6 nM, respectively). Cabozantinib displays strong inhibition of […]