Name: AZD-1480
CAS#: 935666-88-9
Chemical Formula: C14H14ClFN8
Exact Mass: 348.1014
Molecular Weight: 348.76596
Elemental Analysis: C, 48.21; H, 4.05; Cl, 10.17; F, 5.45; N, 32.13
Description: AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.
