Rebastinib

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Name: Rebastinib
CAS#: 1020172-07-9
Chemical Formula: C30H28FN7O3
Exact Mass: 553.22377
Molecular Weight: 553.59
Elemental Analysis: C, 65.09; H, 5.10; F, 3.43; N, 17.71; O, 8.67
Description: Rebastinib, also known as DCC-2036, is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor DCC-2036 binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. Multitargeted tyrosine kinase inhibitor DCC-2036 may exhibit more potent activity against T315I Bcr-Abl gatekeeper mutant kinases than other Bcr-Abl kinase inhibitors

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