KPT-9274
Cat No:LP000339 Product Name:KPT-9274 CAS#1643913-93-2 KPT-9274 is a dual inhibitor of nicotinamide phosphoribosyltransferase (NAMPT; IC50 = 120 nM) and the serine/threonine protein kinase PAK4.1 It selectively inhibits the phosphorylation of PAK4 in renal cell carcinoma cells over normal renal tubular epithelium, and U2OS cells with a PAK4 knockout exhibit a 6-fold resistance to growth inhibition […]