LY2811376

Active small molecule, Products,

Cat No:LP000140 Product Name:LY2811376 CAS No:1194044-20-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C Accumulation of the β-amyloid (Aβ) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer’s disease.1 Aβ is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase.2 LY2811376 is […]

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MK-5108

Active small molecule, Products, ,

Cat No:LP000139 Product Name:MK-5108,VX689 CAS No:1010085-13-8 Purity: ≥99% Solubility: In DMSO Storage: -10°C MK-5108 inhibits Aurora-A activity with an IC50 value of 0.064 nM in an ATP-competitive manner. It shows robust selectivity against the other family kinases Aurora-B (220-fold) and Aurora-C (190-fold). MK-5108 also exhibits high selectivity for Aurora-A over other protein kinases. MK-5108 inhibits […]

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