Abiraterone

Active small molecule, Products, ,

Cat No:LP000150 Product Name:Abiraterone;CB-7598 CAS No:154229-19-3 Purity: ≥99% Solubility: In DMSO Storage: -10°C Significant inhibition of proliferation of the AR-positive prostate cancer cell lines LNCaP and VCaP with doses of Abiraterone ≥5 μM is confirmed[2]. Abiraterone shows IC50 values of 15 nM and 2.5 nM for the 17,20-lyase and 17α-hydroxylase (CYP17 is a bifunctional enzyme […]

READ MORE

R547

Active small molecule, Products,

Cat No:LP000149 Product Name:R547 CAS No:741713-40-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. IC50 Value: 2 nM(Ki for CDK1); 3 nM(Ki for CDK2); 1 nM(Ki for CDK4) Target: CDK in vitro: R547 effectively inhibits CDK1/cyclinB, CDK2/cyclinE, and CDK4/cyclinD1(Ki=1-3nM) and is […]

READ MORE