LookPharma – Page 611 – Look Pharma Limited

BIX02189

Feb 25, 2018adminActive small molecule, Products1265916-41-3, BIX02189

Cat No:LP000260 Product Name:BIX02189 CAS No:1265916-41-3 Purity: ≥99% Solubility: In DMSO Storage: -10°C MEK5, also known as MAP2K5, phosphorylates ERK5 (MAPK7) in signaling pathways involved in stress-induced apoptosis, neuronal survival, cardiac development, and angiogenesis.1,2 BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of […]

BIX02188

Cat No:LP000259 Product Name:BIX02188 CAS No:334949-59-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively).1 It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = […]