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SAR245409(Voxtalisib)

Cat No:LP000272 Product Name:SAR245409,Voxtalisib,XL765 CAS No:934493-76-2 Purity: ≥99% Solubility: In DMSO Storage: -10°C SAR245409 (XL765) displays potent inhibitory activity against class I PI3K isoforms p110α, p110β, p110δ, and p120γ, with IC50s of 39, 110, 43, and 9 nM, respectively. The IC50 value for inhibition of PI3Kα by SAR245409 is determined at various concentrations of ATP, […]

SKLB610

Feb 25, 2018adminActive small molecule, Products1125780-41-7, SKLB610

Cat No:LP000271 Product Name:SKLB610 CAS No:1125780-41-7 Purity: ≥99% Solubility: In DMSO Storage: -10°C SKLB610 has a selective inhibition of VEGF-induced proliferation with an IC50 value of 2.2μM. In HUVECs, SKLB610 shows selectivity of 2-fold for inhibition of VEGF-induced proliferation versus bFGF-induced proliferation with an IC50 value of 4.7μM. In HUVECs, SKLB610 blocks VEGF stimulated phosphorylation […]