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UNC1999

Feb 25, 2018adminActive small molecule, Products1431612-23-5, UNC1999

Cat No:LP000288 Product Name:UNC1999 CAS No:1431612-23-5 Purity:≥99% Solubility:In DMSO Storage:-10°C The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer.1 UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 […]

PJ-34

Feb 25, 2018adminActive small molecule, Products344458-15-7, PJ34

Cat No:LP000287 Product Name:PJ34(hydrochloride) CAS No:344458-15-7 Purity:≥99% Solubility:In DMSO Storage:-10°C The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.1,2 PJ-34 is an inhibitor of PARPs which can be used in cells or in animals.3,4,5 It binds and inhibits the […]