Cat No:LP000306 Product Name:Elafibranor;GFT505 CAS#923978-27-2 Molecular Formula C22H24O4S Molecular Weight 384.49 GFT505 is being developed as a dual PPAR-α/PPAR-δ agonist for the treatment of T2DM and non-alcoholic fatty liver disease. GFT505 has an active metabolite, GFT1007, and both have potent agonist activity for PPAR-α and to a lesser extent for PPAR-δ[1]. GFT505 improves insulin sensitivity […]
Cat No:LP000305 Product Name:SR9009 Synonyms:3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester CAS#1379686-30-2 Molecular Formula:C20H24ClN3O4S Molecular Weight:437.94 SR9009 dose-dependently increases the REV-ERB-dependent repressor activity assessed in HEK293 cells expressing a chimeric Gal4 DNA Binding Domain (DBD)-REV-ERB ligand binding domain (LBD)α or β and a Gal4-responsive luciferase reporter (SR9009: REV-ERBα IC50=670 nM, REV-ERBβ IC50=800 nM). SR9009 potently and efficaciously suppresses […]