UNC0379

Active small molecule, Products,

Cat No:LP000310 Product Name:UNC0379 CAS#1620401-82-2 Molecular Formula:C23H35N5O2 Molecular Weight:413.56 UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. IC50 value: 7.3±1.0 uM Target: SETD8 inhibitor UNC0379 is a synthetic small-molecule inhibitor that displays inhibitory activity in multiple biochemical assays and is selective for […]

READ MORE

BIX-01294

Active small molecule, Products,

Cat No:LP000309 Product Name:BIX-01294 CAS#935693-62-2 Molecular Formula:C28H38N6O2 Molecular Weight:490.64 BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes[1]. BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced […]

READ MORE