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MSX-122

Jun 20, 2018adminActive small molecule, Products897657-95-3, MSX-122

Cat No:LP000316 Product Name:MSX-122 CAS#897657-95-3 Molecular Formula:C16H16N6 Molecular Weight:292.34 MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).1 It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and […]

NIBR189

Jun 18, 2018adminActive small molecule, Products1599432-08-2, NIBR189

Cat No:LP000315 Product Name:NIBR189 CAS#1599432-08-2 Molecular Formula:C21H21BrN2O3 Molecular Weight:429.31 Epstein-Barr virus-induced G protein-coupled receptor 2 (EBI2, also known as GPR183) is an oxysterol receptor involved in B cell migration and function.1 NIBR189 is an antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors, respectively).2 It is selective for EBI2 over […]