GSK369796

Active small molecule, Products,

Cat No:LP000326 Product Name:GSK369796 CAS#1010411-21-8 Molecular Formula:C20H22ClN3O.2(HCl) Molecular Weight:428.79 In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC50s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar […]

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PCI 34051

Active small molecule, Products,

Cat No:LP000325 Product Name:PCI 34051 CAS#950762-95-5 Molecular Formula:C17H16N2O3 Molecular Weight:296.32 PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively).1 PCI 34051 induces caspase-dependent apoptosis in cell lines derived […]

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