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JNJ-7706621

Jun 21, 2018adminActive small molecule, Products443797-96-4, JNJ-7706621

Cat No:LP000330 Product Name:JNJ-7706621 CAS#443797-96-4 Molecular Formula:C15H12F2N6O3S Molecular Weight:394.36 JNJ-7706621 shows antiproliferative activity against various human tumor cells with IC50s of 284, 254, and 447 nM for HeLa, HCT116, and A375, respectively[1]. JNJ-7706621 inhibits other centrosomal proteins such as TOG, Nek2, and TACC3 in early mitotic phase, but does not prevent localization of Aurora A […]

BAY 61-3606

Cat No:LP000329 Product Name:BAY 61-3606 CAS#732983-37-8 Molecular Formula:C20H18N6O3 Molecular Weight:390.40 BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. IC50 value: 7.5 nM (Ki) [1] Target: Syk in vitro: BAY 61-3606 inhibited not only […]