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Relugolix

Jun 25, 2018adminActive small molecule, Products737789-87-6, Relugolix, TAK-385

Cat No:LP000342 Product Name:Relugolix;TAK-385 CAS#737789-87-6 Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013. target: GnRH [1] IC50: 0.33 nM [1] In vivo: In female knock-in mice, twice-daily oral […]

ML355

Cat No:LP000341 Product Name:ML355 CAS#1532593-30-8 ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties. IC50 value: 0.34 μM [1] Target: 12-LOX ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.