Cat No:LP000354 Product Name:RVX-208;Apabetalone;RVX000222 CAS#1044870-39-4 Molecular Formula:C20H22N2O5 Molecular Weight:370.40 RVX-208 competes with binding of an acetylated histone peptide to tandem BD1 BD2 protein constructs of the four BET proteins, with IC50s between 0.5 and 1.8 µM. RVX-208 increases the production of ApoA-I in hepatocytes in vitro, which results in increased high density lipoprotein cholesterol (HDL-C). […]
Cat No:LP000353 Product Name:Acalabrutinib;ACP-196 CAS#1420477-60-6 Molecular Formula:C26H23N7O2 Molecular Weight:465.51 In the human CLL NSG xenograft model, acalabrutinib demonstrates on-target effects including decreased phosphorylation of PLCγ2, ERK and significant inhibition of CLL cell proliferation. Acalabrutinib significantly decreases tumor burden in the spleen of the mice. In the TCL1 adoptive transfer model, acalabrutinib treatment decreases phosphorylation of […]