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Monastrol

Jul 5, 2018adminActive small molecule, Products329689-23-8, Monastrol

Cat No:LP000372 Product Name:Monastrol;(±)-Monastrol CAS#329689-23-8 Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family. Monastrol treatment of dividing cells results in spindle collapse and cell cycle arrest with a monoastral spindle, which is similar to the phenotype observed when Eg5 is inhibited by […]

SF2523

Jul 5, 2018adminActive small molecule, Products1174428-47-7, SF2523

Cat No:LP000371 Product Name:SF2523 CAS#1174428-47-7 SF2523 treatment decreases protein levels of MYCN and Cyclin D1, the MYCN target, and inhibits AKT activation by blocking phosphorylation of AKT at Ser473. SF2523 treatment leads to the displacement of BRD4 from both MYCN promoter sites. SF2523 interacts robustly with the full-length BRD4 (Kd=140 nM) and exhibits comparable affinity […]