Cat No:LP000376 Product Name:Bohemine CAS#189232-42-6 Bohemine is a purine derivative that inhibits cyclin-dependent kinases (Cdks) (IC50s = 4.6, 8.3, and 2.7 µM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively).1 It has been shown to suppress cell growth and induce G1 and G2 phase cell cycle arrest in hybridoma cells.
Cat No:LP000375 Product Name:M2I-1 CAS#312271-03-7 M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the Mad2-F-Mbp1 interaction in FP assays.