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Poseltinib

Jul 6, 2018adminActive small molecule, Products1353562-97-2, Poseltinib

Cat No:LP000392 Product Name:Poseltinib CAS#1353562-97-2 Poseltinib, also known HM-71224 and LY3337641, is a tyrosine kinase inhibitor. Poseltinib is an experimental Bruton’s tyrosine kinase inhibitor for the treatment of rheumatoid arthritis. HM71224 irreversibly bound to and inhibited Btk (IC50 = 1.95 nM). The compound also inhibited the phosphorylation of Btk and its downstream molecules such as PLCγ2, in […]

AD80

Cat No:LP000391 Product Name:AD80 CAS#1384071-99-1 AD80 is a polypharmacological agent with an optimal balance of activity against Ret, Raf, Src, Tor and S6K that show high efficacy with very low toxicity. AD80 and AD81 inhibits RET, RAF, SRC and S6K, with greatly reduced mTOR activity relative to AD57 and AD58.AD80 is optimal for Ras–Erk pathway […]