LookPharma – Page 544 – Look Pharma Limited

Cerdulatinib

Jul 6, 2018adminActive small molecule, Products1198300-79-6, Cerdulatinib, PRT062070

Cat No:LP000394 Product Name:Cerdulatinib；PRT062070；PRT2070 CAS#1198300-79-6 Cerdulatinib shows inhibitory effect on 60 CLL with IC50 ranging from 0.37 to 10.02 µM. Cerdulatinib induces apoptosis in CLL in association with MCL-1 down-regulation and PARP cleavage. Cerdulatinib (2μM) is able to overcome the support of the microenvironment and induces CLL cell death. Cerdulatinib (250-500 nM) blocks proliferation of […]

AST 487

Cat No:LP000393 Product Name:AST 487;NVP-AST 487 CAS#630124-46-8 A number of other kinases are also similarly inhibited by AST 487 (NVP-AST487) in the in vitro kinase assays, including KDR (IC50=170 nM), Flt-4 (IC50=790 nM), Flt-3 (IC50=520 nM), c-Kit (IC50=500 nM), and c-Abl (IC50=20 nM). AST 487 potently inhibits the growth of human thyroid cancer cell lines […]