EPZ-6438

Active small molecule, Products, , ,

Cat No:LP000402 Product Name:EPZ-6438;Tazemetostat;E-7438 CAS#1403254-99-8 EPZ-6438 inhibits EZH2 in a manner competitive with the substrate S-adenosylmethionine (SAM). EPZ-6438 inhibits EZH1, EZH2(in peptide assay), EZH2 (in nucleosome assay) with IC50of 392 nM, 11 nM and 16 nM, respectively. EPZ-6438 displays a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs tested[1]. EPZ-6438 (125 […]

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CHF5074

Active small molecule, Products,

Cat No:LP000401 Product Name:CHF5074；CSP-1103; Itanapraced CAS#749269-83-8 CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. IC50 value: 3.6 μM (Aβ42), 18.4 μM (Aβ40) [1] Target: γ-secretase in vitro: CHF5074 significantly reduces the area occupied by plaques and the number of plaques in cortex and […]

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