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Azoramide

Jul 17, 2018adminActive small molecule, Products932986-18-0, Azoramide

Cat No:LP000414 Product Name:Azoramide CAS#932986-18-0 Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. in vitro: Azoramide is a dual-function endoplasmic reticulum (ER) modulator. Azoramide improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. Azoramide regulates ER folding and secretion capacity without […]

AZD3759

Cat No:LP000413 Product Name:AZD3759 CAS#1626387-80-1 At 2 mM of ATP concentrations, the IC50s are 102, 7.6, and 2.4 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively. AZD3759 also inhibits pEGFR in H838wt, H3255L858R, and PC-9exon 19Del with IC50 of 64.5, 7.2, and 7.4 nM, respectively. In cellular phosphorylation studies, AZD3759 also demonstrates 9-fold inhibition selectivity […]