Active small molecule – Page 708

JNJ-31020028

Aug 18, 2017adminActive small molecule, Products1094873-14-9, JNJ-31020028

Cat No:LP000023 Product Name:JNJ-31020028 CAS:1094873-14-9 Purity:99%+ In Stock JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. IC50 value: 8.07/8.22(human/rat pIC50) [1] Target: Y2 receptor antagonist in vitro: JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04 +/- 0.13) in […]

LY2090314

Cat No:LP000022 Product Name:LY2090314 CAS:603288-22-8 Purity:99%+ In Stock LY2090314 (20 nM) promotes a time-dependent stabilization of β-catenin total protein as well as an induction of Axin2. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases. LY2090314 potently induces apoptotic cell death in a panel of […]