Active small molecule – Page 705

Madrasin

Aug 18, 2017adminActive small molecule, Products374913-63-0, Madrasin

Cat No:LP000029 Product Name:Madrasin,DDD00107587 CAS:374913-63-0 Purity:99%+ In Stock Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs […]

GZD824

Cat No:LP000028 Product Name:GZD824,GZD-824 CAS:1257628-77-5 Purity:99%+ In Stock GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. IC50 Value: 0.34/0.68 nM(Bce-Abl wt/T315I) [1] Target: Bcr-Abl in vitro: GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50) values of […]