Active small molecule – Page 704

CH5183284

Aug 18, 2017adminActive small molecule, Products1265229-25-1, CH5183284

Cat No:LP000031 Product Name:CH5183284,Debio-1347 CAS:1265229-25-1 Purity:99%+ In Stock CH5183284 is well balanced in cellular antiproliferative activity against SNU-16 and stability in human liver microsome. The selectivity of 8 to inhibit FGFR over KDR is suggested to be caused by the difference in the interaction with M535 in FGFR1 and L889 in KDR[1]. The IC50 of […]

AZD9496

Aug 18, 2017adminActive small molecule, Products1639042-08-2, AZD9496

Cat No:LP000030 Product Name:AZD9496 CAS:1639042-08-2 Purity:99%+ In Stock The potency of AZD9496 with IC50 of 0.82 nM, 0.14 nM, and 0.28 nM in ERα binding, downregulation, and antagonism, respectively. AZD9496 significantly inhibits MCF-7 cell growth with EC50 of 0.04 nM[1]. Selectivity of AZD9496 over other tested nuclear hormone receptors is high: androgen receptor (AR), IC50=30 […]