Cat No:LP000074 Product Name:LY2886721;β-Secretase CAS NO:1262036-50-9 Purity: ≥99% Solubility: In DMSO Storage: -10°C LY2886721 selectively inhibits the β-site amyloid protein cleaving enzyme (BACE) (IC50 = 20 nM for recombinant hBACE1).1 BACE performs the first cleavage step in the Aβ cascade; thus, its inhibition by LY2886721 decreases production of all forms of the Aβ peptide.2 A […]
Cat No:LP000073 Product Name:PF-05212384;PKI-587;PK-1587 CAS NO:1197160-78-3 Purity: ≥99% Solubility: In DMSO Storage: -10°C Phosphatidylinositol-3-kinases (PI3Ks) act in concert with mTOR complexes to regulate signaling pathways that have critical roles in cancer and other diseases.1,2 PF-05212384 is a potent, dual PI3K/mTOR inhibitor (IC50 values are 0.4 and 5.4 nM for PI3Kα and PI3Kγ, respectively, and 1.6 […]