Active small molecule – Page 677

(R)-Roscovitine

Cat No:LP000098 Product Name:(R)-Roscovitine;Seliciclib CAS NO:186692-46-6 Purity: ≥99% Solubility: In DMSO Storage: -10°C Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.1 It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division […]

MGCD-265

Feb 22, 2018adminActive small molecule, Products875337-44-3, MGCD265

Cat No:LP000097 Product Name:MGCD265;Glesatinib CAS NO:875337-44-3 Purity: ≥99% Solubility: In DMSO Storage: -10°C MGCD-265 is an orally bioavailable, multi-targeted tyrosine kinase inhibitor, inhibiting MET, VGFR1-3, Tie, and Ron. Formulations containing MGCD-265, alone or in combination with other chemotherapeutic compounds, are being tested in animal models and clinical cancer trials, particularly for non-small cell lung cancer.