Active small molecule – Page 556

LX2343

Jun 23, 2018adminActive small molecule, Products333745-53-2, LX2343

Cat No:LP000340 Product Name:LX2343 CAS#333745-53-2 LX2343 (5-20 μM) dose-dependently decreased Aβ accumulation in HEK293-APPsw and CHO-APP cells, and promotes Aβ clearance in SH-SY5Y cells and primary astrocytes. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion, which highlights the potential of LX2343 in the treatment of AD. Western […]

KPT-9274

Cat No:LP000339 Product Name:KPT-9274 CAS#1643913-93-2 KPT-9274 is a dual inhibitor of nicotinamide phosphoribosyltransferase (NAMPT; IC50 = 120 nM) and the serine/threonine protein kinase PAK4.1 It selectively inhibits the phosphorylation of PAK4 in renal cell carcinoma cells over normal renal tubular epithelium, and U2OS cells with a PAK4 knockout exhibit a 6-fold resistance to growth inhibition […]