Active small molecule – Page 515

AMG 517

Jul 17, 2018adminActive small molecule, Products659730-32-2, AMG 517

Cat No:LP000422 Product Name:AMG 517 CAS#659730-32-2 AMG 517 retains potency in the capsaicin- and acid-mediated assays with IC50 values of 0.9 and 0.5 nM[1]. AMG 517 inhibits capsaicin, pH 5, and heat-induced45Ca2+ uptake into cells expressing TRPV1 with IC50 values of 1 to 2 nM. AMG 517 blocks capsaicin-, proton-, and heat-induced inward currents in […]

GRA Ex-25

Jul 17, 2018adminActive small molecule, Products307983-31-9, GRA Ex-25

Cat No:LP000421 Product Name:GRA Ex-25 CAS#307983-31-9 GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions[1]. GRA Ex-25 has similar affinity to the rat and human glucagon receptors (IC50=56 and 55 nM, respectively). GRA […]