Active small molecule – Page 249

TG100-115

Sep 5, 2018adminActive small molecule677297-51-7, TG100-115

Name: TG100-115 CAS#: 677297-51-7 Chemical Formula: C18H14N6O2 Exact Mass: 346.11782 Molecular Weight: 346.34276 Elemental Analysis: C, 62.42; H, 4.07; N, 24.27; O, 9.24 Description: TG100-115, inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively), whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM). As a gauge of general specificity, […]

AZ3146

Sep 5, 2018adminActive small molecule1124329-14-1, AZ3146

Name: AZ3146 CAS#: 1124329-14-1 Chemical Formula: C24H32N6O3 Exact Mass: 452.25359 Molecular Weight: 452.55 Elemental Analysis: C, 63.70; H, 7.13; N, 18.57; O, 10.61 Description: AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1’s catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. […]