Active small molecule

Pictilisib

Cat No:LP000007 Product Name:Pictilisib,GDC-0941; CAS:957054-33-0 Purity:99%+ In Stock GDC-0941 and docetaxel reduce tumor cell viability by 80% or greater in the breast cancer cell lines than single-agent treatment. GDC-0941 inhibits Akt phosphorylation and downstream targets of Akt signaling such as pPRAS40 and pS6 in Hs578T1.2 (PI3Kα wild-type), MCF7-neo/HER2 (PI3Kα-mutant), and Read More

P7C3-A20

Cat No:LP000004 Product Name:P7C3-A20; CAS:1235481-90-9 Purity:99%+ In Stock P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 exerted an antidepressant-like effect in wild-type littermates than P7C3. display increased activity and an improved toxicity profile compared to P7C3. P7C3 is a NAMPT activator. In vivo: The P7C3-A20 Read More

SB216763

Cat No:LP000002 Product Name: SB 216763 ; Chem Name:3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; CAS: 280744-09-4 Purity:99%+ In Stock SB-216763 (10-20 µM) induces β-catenin mediated-transcription in a dose-dependent manner in HEK293 cells. SB-216763 (10, 15 and 20 µM) can maintain mESCs with a pluripotent-like morphology in long-term culture. SB-216763 (10 µM) can maintain J1 mESCs Read More

OTSSP167

Cat No:LP000001 Product Name:OTSSP167 CAS:1431697-89-0 Formula:C25H28Cl2N4O2 Purity:99%+ Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes.1 MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors.2,3,4 OTSSP167 is a potent Read More