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Galunisertib

Cat No:LP000008 Product Name:Galunisertib,LY2157299; CAS:700874-72-2 Purity:99%+ In Stock LY2157299 (Galunisertib) is a selective ATP-mimetic inhibitor of TGF-β receptor (TβR)-I activation LY2157299 (0.1, 1, 10, and 100 μM) displays a slight dose-dependent potentiation of Sorafenib in SK-Sora, HepG2, and Hep3B cell lines but not in JHH6, SK-HEP1, and HuH7 cell lines[2]. Human xenografts Calu6 (non-small cell […]

Pictilisib

Aug 17, 2017adminActive small molecule, Products957054-33-0, GDC-0941, Pictilisib

Cat No:LP000007 Product Name:Pictilisib,GDC-0941; CAS:957054-33-0 Purity:99%+ In Stock GDC-0941 and docetaxel reduce tumor cell viability by 80% or greater in the breast cancer cell lines than single-agent treatment. GDC-0941 inhibits Akt phosphorylation and downstream targets of Akt signaling such as pPRAS40 and pS6 in Hs578T1.2 (PI3Kα wild-type), MCF7-neo/HER2 (PI3Kα-mutant), and MX-1 (PTEN-null) tumor models. GDC-0941 […]