Cat No:LP000297
Product Name:TCS 1102
CAS No:916141-36-1
Purity:≥98%
Solubility:In DMSO
Storage:at -20°C 2 years
Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively).1 It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally.1 Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse.2 Systemic injection of TCS 1102 (10 mg/kg i.p.) in rats decreases fear and anxiety in response to acute episodes of stress.
