Cat No:LP000271
Product Name:SKLB610
CAS No:1125780-41-7
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
SKLB610 has a selective inhibition of VEGF-induced proliferation with an IC50 value of 2.2μM. In HUVECs, SKLB610 shows selectivity of 2-fold for inhibition of VEGF-induced proliferation versus bFGF-induced proliferation with an IC50 value of 4.7μM. In HUVECs, SKLB610 blocks VEGF stimulated phosphorylation of VEGFR2 in a dose dependent manner after SKLB610 treatment. SKLB610 significant inhibits HUVECs capillary tube formation in a concentration-dependent manner. SKLB610 inhibits the formation of vessel-like structures at 2.5 μM
