Cat No:LP000086
Product Name:GDC-0980;Apitolisib;RG7422
CAS NO:1032754-93-0
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively, in cell-free assays.1,2 It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases.1,2 GDC-0980 induces cell cycle arrest or apoptosis in a range of cancer cell lines.2 It is effective in vivo, suppressing the growth of a number of tumor xenografts in mice and enhancing the antitumor activity of docetaxel (Item No. 11637) in mice.
